8,559 research outputs found
Measured and predicted shock shapes for AFE configuration at Mach 6 in air and in CF4
Shock shapes and stand-off distances were obtained for the Aeroassist Flight Experiment configuration from Mach 6 tests in air and in CF4. Results were plotted for an angle-of attack range from -10 to 10 degrees and comparisons were made at selected angles with inviscid-flow predictions. Tests were performed in the Langley Research Center (LaRC) 20 inch Mach 6 Tunnel (air) at unit free-stream Reynolds numbers (N sub Re, infinity) of 2 million/ft and 0.6 million/ft and in the LaRC Hypersonic CF4 Tunnel at N sub Re, infinity = 0.5 million/ft and 0.3 million/ft. Within the range of these tests, N sub Re, infinity did not affect the shock shape or stand off distance, and the predictions were in good agreement with the measurements. The shock stand-off distance in CF4 was approximately half of that in air. This effect resulted from the differences in density ratio across the normal shock, which was approximately 12 in CF4 and 5 in air. In both test gases, the shock lay progressively closer to the body as angle of attack decreased
Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay.
Many gene expression factors contain repetitive phosphorylation sites for single kinases, but the functional significance is poorly understood. Here we present evidence for hyperphosphorylation as a mechanism allowing UPF1, the central factor in nonsense-mediated decay (NMD), to increasingly attract downstream machinery with time of residence on target mRNAs. Indeed, slowing NMD by inhibiting late-acting factors triggers UPF1 hyperphosphorylation, which in turn enhances affinity for factors linking UPF1 to decay machinery. Mutational analyses reveal multiple phosphorylation sites contributing to different extents to UPF1 activity with no single site being essential. Moreover, the ability of UPF1 to undergo hyperphosphorylation becomes increasingly important for NMD when downstream factors are depleted. This hyperphosphorylation-dependent feedback mechanism may serve as a molecular clock ensuring timely degradation of target mRNAs while preventing degradation of non-targets, which, given the prevalence of repetitive phosphorylation among central gene regulatory factors, may represent an important general principle in gene expression
A Classification of Minimal Sets of Torus Homeomorphisms
We provide a classification of minimal sets of homeomorphisms of the
two-torus, in terms of the structure of their complement. We show that this
structure is exactly one of the following types: (1) a disjoint union of
topological disks, or (2) a disjoint union of essential annuli and topological
disks, or (3) a disjoint union of one doubly essential component and bounded
topological disks. Periodic bounded disks can only occur in type 3. This result
provides a framework for more detailed investigations, and additional
information on the torus homeomorphism allows to draw further conclusions. In
the non-wandering case, the classification can be significantly strengthened
and we obtain that a minimal set other than the whole torus is either a
periodic orbit, or the orbit of a periodic circloid, or the extension of a
Cantor set. Further special cases are given by torus homeomorphisms homotopic
to an Anosov, in which types 1 and 2 cannot occur, and the same holds for
homeomorphisms homotopic to the identity with a rotation set which has
non-empty interior. If a non-wandering torus homeomorphism has a unique and
totally irrational rotation vector, then any minimal set other than the whole
torus has to be the extension of a Cantor set.Comment: Published in Mathematische Zeitschrift, June 2013, Volume 274, Issue
1-2, pp 405-42
Thermodynamic anomalies in a lattice model of water: Solvation properties
We investigate a lattice-fluid model of water, defined on a 3-dimensional
body-centered cubic lattice. Model molecules possess a tetrahedral symmetry,
with four equivalent bonding arms. The model is similar to the one proposed by
Roberts and Debenedetti [J. Chem. Phys. 105, 658 (1996)], simplified by
removing distinction between "donors" and "acceptors". We focus on solvation
properties, mainly as far as an ideally inert (hydrophobic) solute is
concerned. As in our previous analysis, devoted to neat water [J. Chem. Phys.
121, 11856 (2004)], we make use of a generalized first order approximation on a
tetrahedral cluster. We show that the model exhibits quite a coherent picture
of water thermodynamics, reproducing qualitatively several anomalous properties
observed both in pure water and in solutions of hydrophobic solutes. As far as
supercooled liquid water is concerned, the model is consistent with the second
critical point scenario.Comment: 12 pages, 9 figures, 1 tabl
Evaluating weaknesses of "perceptual-cognitive training" and "brain training" methods in sport: An ecological dynamics critique
The recent upsurge in "brain training and perceptual-cognitive training," proposing to improve isolated processes, such as brain function, visual perception, and decision-making, has created significant interest in elite sports practitioners, seeking to create an "edge" for athletes. The claims of these related "performance-enhancing industries" can be considered together as part of a process training approach proposing enhanced cognitive and perceptual skills and brain capacity to support performance in everyday life activities, including sport. For example, the "process training industry" promotes the idea that playing games not only makes you a better player but also makes you smarter, more alert, and a faster learner. In this position paper, we critically evaluate the effectiveness of both types of process training programmes in generalizing transfer to sport performance. These issues are addressed in three stages. First, we evaluate empirical evidence in support of perceptual-cognitive process training and its application to enhancing sport performance. Second, we critically review putative modularized mechanisms underpinning this kind of training, addressing limitations and subsequent problems. Specifically, we consider merits of this highly specific form of training, which focuses on training of isolated processes such as cognitive processes (attention, memory, thinking) and visual perception processes, separately from performance behaviors and actions. We conclude that these approaches may, at best, provide some "general transfer" of underlying processes to specific sport environments, but lack "specificity of transfer" to contextualize actual performance behaviors. A major weakness of process training methods is their focus on enhancing the performance in body "modules" (e.g., eye, brain, memory, anticipatory sub-systems). What is lacking is evidence on how these isolated components are modified and subsequently interact with other process "modules," which are considered to underlie sport performance. Finally, we propose how an ecological dynamics approach, aligned with an embodied framework of cognition undermines the rationale that modularized processes can enhance performance in competitive sport. An ecological dynamics perspective proposes that the body is a complex adaptive system, interacting with performance environments in a functionally integrated manner, emphasizing that the inter-relation between motor processes, cognitive and perceptual functions, and the constraints of a sport task is best understood at the performer-environment scale of analysis
Airline Liability for Loss, Damage or Delay of Passenger Baggage
The article discusses remedies and methods of enforcing airline liability for loss, damage or delay of passenger baggage. The article includes a discussion of the law as it relates both to domestic flights and to international flights where passenger luggage is lost, damaged or delayed. The article includes a discussion of the Warsaw Convention as it relates to international flights and of the Federal Aviation Regulations applicable in the case of domestic flights
Cluster-variation approximation for a network-forming lattice-fluid model
We consider a 3-dimensional lattice model of a network-forming fluid, which
has been recently investigated by Girardi and coworkers by means of Monte Carlo
simulations [J. Chem. Phys. \textbf{126}, 064503 (2007)], with the aim of
describing water anomalies. We develop an approximate semi-analytical
calculation, based on a cluster-variation technique, which turns out to
reproduce almost quantitatively different thermodynamic properties and phase
transitions determined by the Monte Carlo method. Nevertheless, our calculation
points out the existence of two different phases characterized by long-range
orientational order, and of critical transitions between them and to a
high-temperature orientationally-disordered phase. Also, the existence of such
critical lines allows us to explain certain ``kinks'' in the isotherms and
isobars determined by the Monte Carlo analysis. The picture of the phase
diagram becomes much more complex and richer, though unfortunately less
suitable to describe real water.Comment: 10 pages, 9 figures, submitted to J. Chem. Phy
Efficient algorithms for tensor scaling, quantum marginals and moment polytopes
We present a polynomial time algorithm to approximately scale tensors of any
format to arbitrary prescribed marginals (whenever possible). This unifies and
generalizes a sequence of past works on matrix, operator and tensor scaling.
Our algorithm provides an efficient weak membership oracle for the associated
moment polytopes, an important family of implicitly-defined convex polytopes
with exponentially many facets and a wide range of applications. These include
the entanglement polytopes from quantum information theory (in particular, we
obtain an efficient solution to the notorious one-body quantum marginal
problem) and the Kronecker polytopes from representation theory (which capture
the asymptotic support of Kronecker coefficients). Our algorithm can be applied
to succinct descriptions of the input tensor whenever the marginals can be
efficiently computed, as in the important case of matrix product states or
tensor-train decompositions, widely used in computational physics and numerical
mathematics.
We strengthen and generalize the alternating minimization approach of
previous papers by introducing the theory of highest weight vectors from
representation theory into the numerical optimization framework. We show that
highest weight vectors are natural potential functions for scaling algorithms
and prove new bounds on their evaluations to obtain polynomial-time
convergence. Our techniques are general and we believe that they will be
instrumental to obtain efficient algorithms for moment polytopes beyond the
ones consider here, and more broadly, for other optimization problems
possessing natural symmetries
Revisiting waterlike network-forming lattice models
In a previous paper [J. Chem. Phys. 129, 024506 (2008)] we studied a 3
dimensional lattice model of a network-forming fluid, recently proposed in
order to investigate water anomalies. Our semi-analytical calculation, based on
a cluster-variation technique, turned out to reproduce almost quantitatively
several Monte Carlo results and allowed us to clarify the structure of the
phase diagram, including different kinds of orientationally ordered phases.
Here, we extend the calculation to different parameter values and to other
similar models, known in the literature. We observe that analogous ordered
phases occur in all these models. Moreover, we show that certain "waterlike"
thermodynamic anomalies, claimed by previous studies, are indeed artifacts of a
homogeneity assumption made in the analytical treatment. We argue that such a
difficulty is common to a whole class of lattice models for water, and suggest
a possible way to overcome the problem.Comment: 13 pages, 12 figure
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